The John Wayne Casserole is a delicious, hearty dish that’s perfect for family dinners or gatherings. Named after the famous actor, this casserole features layers of seasoned ground beef, vegetables, and a rich biscuit base, all topped with a creamy cheese mixture. It’s the ultimate comfort food with Southwestern flair, and it’s easy to make with ingredients you likely have on hand. Let’s dive in and make this crowd-pleasing dish!
Table of Contents
- Introduction
- Ingredients
- Instructions
- Cook Notes & Tips
- Variations
- Frequently Asked Questions (FAQs)
- Conclusion
Introduction
John Wayne Casserole is a dish packed full of bold flavors that bring together the essence of the Old West. It’s named after the iconic actor, and some say the recipe came from a dish he loved. Featuring layers of biscuits, spiced ground beef, bell peppers, onions, tomatoes, and a cheesy topping, this dish is comforting, easy to make, and perfect for feeding a crowd. With its combination of savory flavors and creamy textures, this casserole will have everyone coming back for seconds.
Ingredients
For the Casserole Base
- 1 pound ground beef
- 1 medium onion, chopped
- 1 red bell pepper, chopped
- 1 green bell pepper, chopped
- 1 (10-ounce) can diced tomatoes with green chilies (such as Ro*Tel), drained
- 1 (1-ounce) packet taco seasoning
- 1 (8-ounce) can refrigerated biscuit dough
For the Topping
- 1 cup sour cream
- 1/2 cup mayonnaise
- 1 cup shredded cheddar cheese
- 1 cup shredded Monterey Jack cheese
- 1/4 teaspoon garlic powder
- 1/4 teaspoon onion powder
- Salt and pepper to taste
Instructions
- Preheat the Oven: Preheat your oven to 350°F (175°C). Grease a 9×13-inch baking dish with cooking spray.
- Cook the Ground Beef: In a large skillet over medium heat, cook the ground beef until browned. Drain excess fat, then add the chopped onion, red bell pepper, and green bell pepper. Cook for 5-6 minutes until the vegetables are softened.
- Season the Beef: Add the taco seasoning and diced tomatoes with green chilies to the skillet. Stir until everything is well combined, and let it simmer for 2-3 minutes. Remove from heat and set aside.
- Prepare the Biscuit Base: Open the can of biscuit dough and press the dough evenly into the bottom of the prepared baking dish to form a crust.
- Layer the Casserole: Spread the cooked ground beef mixture evenly over the biscuit layer in the baking dish.
- Make the Topping: In a mixing bowl, combine the sour cream, mayonnaise, garlic powder, onion powder, salt, and pepper. Stir in the shredded cheddar and Monterey Jack cheese until well mixed.
- Add the Topping: Spread the cheese mixture evenly over the ground beef layer in the baking dish.
- Bake: Bake the casserole in the preheated oven for 30-35 minutes, or until the top is golden brown and bubbly.
- Cool and Serve: Allow the casserole to cool for about 5 minutes before slicing and serving. Garnish with fresh chopped green onions if desired.
Cook Notes & Tips
- Biscuit Layer: Make sure to press the biscuit dough into an even layer to ensure it cooks evenly.
- Drain Excess Fat: Draining the fat from the cooked ground beef is important to prevent the casserole from becoming greasy.
- Season to Taste: You can adjust the seasonings to your taste, adding more taco seasoning or spices if you prefer a stronger flavor.
Variations
- Spicy Version: Add sliced jalapeños to the beef mixture or use spicy diced tomatoes with green chilies for an extra kick.
- Vegetarian Version: Substitute the ground beef with plant-based ground meat or crumbled tofu, and add extra vegetables like mushrooms or zucchini.
- Add Black Beans: For extra texture and protein, mix in a can of drained black beans with the ground beef mixture.
Frequently Asked Questions (FAQs)
1. Can I Make This Casserole Ahead of Time?
Yes, you can assemble the casserole up to 24 hours in advance. Cover and refrigerate until ready to bake. Add 5-10 minutes to the baking time if starting from cold.
2. How Do I Store Leftovers?
Store any leftovers in an airtight container in the refrigerator for up to 3 days. Reheat in the oven at 350°F (175°C) until warmed through.
3. Can I Freeze This Casserole?
Yes, you can freeze the casserole after baking. Let it cool completely, then cover tightly and freeze for up to 3 months. Thaw in the refrigerator before reheating.
4. What Can I Serve with John Wayne Casserole?
This casserole pairs well with a simple green salad, cornbread, or a side of Mexican rice.
The John Wayne Casserole is a hearty and flavorful dish that is perfect for feeding a crowd or enjoying as a comforting family meal. With its layers of seasoned beef, creamy cheese topping, and biscuit base, it’s easy to see why this casserole has become a classic. Whether you make it for a weeknight dinner or a special gathering, this casserole is sure to satisfy everyone at the table. Give it a try, and experience the taste of the Old West in your kitchen!
Happy Cooking!


where is san manuel casino sites uk no deposit bonus, susanville casino
and top 10 usa gambling sites, or united statesn online poker
2 euro startguthaben casino ohne verifizierung neosurf einzahlung
new zealand choctaw casino games (Ardis) no deposit bonus codes 2021,
free pokie games nz and how to cheat pokie
machines canada, or free spins no deposit slots
united kingdom
online casinos licensed in usa, 5 dollar min deposit casino united states and
new casinos online uk, or android Border Casino united
states
$5 deposit pokies australia, uk online slots sites and betway poker australia, or minimum deposit 1 pound
big fish casino can’t win (https://levitinmobiliaria.com/rojabet-casino-no-deposit-bonus-100-free-spins/) usa
free spins no deposit casinos nz, no deposit bonus on sign up usa and australian dream11 gambling or not, Shawnee, law, or casinos
in united states online
chusachansi casino in fresno california, casino chips value usa and instant payout
casino win bet, Carlos, uk, or live online roulette united states
Gun Lake Casino Monday Specials usa free spins for year, non uk online casino and uk casino 10 no
deposit, or best casino in australia online
las vegas usa casino reviews, online poker in australia legal and ept poker chips in usa,
or uk slot sites not on gamstop
Here is my web blog … best no wager casinos (Celinda)
top online pokies and casinos in united states casino,
free bonus casino no deposit required canada and uk casinos free spins, or free Youwager No Deposit Bonus deposit casino uk 2021
uk casino no deposit bonus no wagering, play real money poker online australia and dollar 1 deposit casino new zealand, or new zealand star el cajon indian casino
new zealandn casino guide 2021, best new zealandn low budget roulette strategy (Makayla) strategy and is playing poker for money
illegal usa, or best casino sites in united states
best online casino low playthrough – Jeffrey – bonuses 2021 usa, how to win at roulette uk and poker stars uk app, or in united statesn roulette
the wheel has 38 numbers
uk free spins 2021, roulette ai automatic and united kingdom online is wind creek Casino open in atmore
no deposit bonus codes 2021, or apple pay online casino united states
list of usa online casinos a to z, free bonus no deposit where Is The
red wind Casino; https://edgeprint.in/Club-uk-casino-no-deposit-bonus/, usa 2021 and au slots bonus codes 2021, or paypal online
casino uk
top online pokies and casinos best baccarat system in the world
united states casino, $150 free no deposit casino australia and new casinos online uk,
or canada online slots
best online casino reviews in united states, how can i
make money with my smartphone in kenya (Melinda) you
play poker online for real money in united kingdom and australian free pokies games, or new zealand star casino
europese roulette mobiel
Feel free to visit my site :: Beste casino bankoverschrijving nederland
juegos de cual es el mejor casino online para ganar Dinero
tragaperrasgratis
online gokkasten prepaid kaart
Feel free to surf to my page – blackjack Switch voor geld
weekend bonus creditcard online casino drunen
beste casino buiten cruks 2025 (Steve) betalen met litecoin
speelautomaten rijswijk
My blog post – Blackjack Zonder Storting
legaal goksite hoge inzet
Also visit my site … Cartes De Bingo Virtuelle
oasis poker lage inzet
Also visit my blog :: casino koksijde entree
video poker casino zonder cruks
my webpage: blackjack Storten met mastercard
gokkasten enschede
Also visit my website beste Casino leeuwarden (https://bhive-Design.com/)
speelautomaten hengelo
Here is my homepage :: beste caribbean stud (eliassonstg.wpenginepowered.com)
types of betting
Also visit my blog … best il sportsbook App
speelhal bree
My web page :: Bonus Buy Gokkasten Online Nederland
mobile sports Betting Terms explained
app
beste online casino kleine 90 ball bingo lage inzet
beste three card poker gokkasten met multiplier nederland
pronósticos casas De apuestas con Bonos deportivas
tenis
Handicap Betting Explained 1×2 tips prediction
how many people bet on the grand national
Here is my web page … Kinsley Greyhound Results Today Live
casino 150 gratis spins
Also visit my web-site; beste goksite Nederland met Cashback
legaal goksite nederland auto roulette voor geld beginners
beste gokkasten met cascading reels
Take a look at my homepage :: Blackjack Casino Vs
casino geld opnemen binnen een uur (https://koochfoundation.com) bredene entree
online 10 euro bonus bij registratie casino met welkomstbonus
apuestas argentina Canada boxeo hoy
deutsche sportwetten lizenz
Look at my homepage … Olympia Basketball Wetten
букмкакво е 1×2 (ergensko.party)йкъри с ePay
goodwood betting odds
Feel free to surf to my blog … where to watch Greyhound racing online
goksite voor gevorderden
Also visit my web page :: casino dinant openingsuren
online casino 15 gratis spins
Also visit my web page … blackjack storten met bankoverschrijving (http://Tonvogt.com/wat-zijn-de-Winnende-kansen-bij-virtuele-gokautomaten/)
total asiatico en apuestas liga de campeones de baloncesto
revolut casino nederland online
Here is my web site … blackjack 5 kaarten regel (Garfield)
sports betting Data analysis betting online app